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Keynote Lecture
Lecture Hall
23.10.2025
14:30 – 15:15h
Keynote Lecture
Chair: Iannis Aifantis
Ontogeny of Human Hematopoiesis: From Stem Cell Emergence to Leukemia Evolution
Hanna Mikkola
14:30h - 15:00h

Lectures
Lecture Hall
22.10.2025
15:15 – 16:00h
Embo Policy Lecture
Chair: John Strouboulis
The challenges of ethical review of stem-cell based therapies
Catriona Jamieson
15:15h - 16:00h

Opening remarks
Lecture Hall
20.10.2025
20:15 – 20:45h
Opening remarks & Welcome Adresses from FEBS
Opening Remarks
Organizing Committee
20:15h - 20:25h

Lectures
Lecture Hall
21.10.2025
08:30 – 10:30h
Aging in hematopoiesis I: bone marrow niche and microenvironment
Chair: Dominique Bonnet
Regeneration of healthy and malignant haematopoiesis: similar sides of two very different coins
Cristina Lo Celso
08:30h - 09:00h

Lectures
Lecture Hall
21.10.2025
08:30 – 10:30h
Aging in hematopoiesis I: bone marrow niche and microenvironment
Chair: Dominique Bonnet
Aging­related spatial remodeling of bone marrow hematopoietic stem­cell microenvironments
Konstantinos Kokkaliaris
09:00h - 09:30h

Lectures
Lecture Hall
21.10.2025
08:30 – 10:30h
Aging in hematopoiesis I: bone marrow niche and microenvironment
Chair: Dominique Bonnet
DNMT3A­R882 mutation intrinsically drives maladaptive myelopoiesis from human haematopoietic stem cells
Elisa Laurenti
09:30h - 10:00h

Lectures
Lecture Hall
21.10.2025
11:45 – 13:45h
Aging in hematopoiesis II: inflammation
Chair: Paresh Vyas
Unlocking inflammatory memory in human hematopoietic stem cells to predict heterogeneous health outcomes
Stephanie Xie
11:45h - 12:15h

Lectures
Lecture Hall
21.10.2025
11:45 – 13:45h
Aging in hematopoiesis II: inflammation
Chair: Paresh Vyas
Early­Life p16 Activation in Oocytes Impairs Hematopoiesis and Immune Competence
Eirini Trompouki
12:15h - 12:45h

Lectures
Lecture Hall
21.10.2025
14:30 – 16:30h
Aging in hematopoiesis III: contribution to systemic aging
Chair: Andreas Trumpp
Regulation of hematopoietic stem cell dormancy
Nina-Cabezas-Wallscheid EMBO Young Investigator Lecture
14:30h - 15:00h

Lectures
Lecture Hall
21.10.2025
14:30 – 16:30h
Aging in hematopoiesis III: contribution to systemic aging
Chair: Andreas Trumpp
Clonal hematopoiesis and the aging brain
Sidd Jaiswal
15:00h - 15:30h

Lectures
Lecture Hall
21.10.2025
14:30 – 16:30h
Aging in hematopoiesis III: contribution to systemic aging
Chair: Andreas Trumpp
Macrophages in the Context of Aging
Claudia Waskow
15:30h - 16:00h

Keynote Lecture
Lecture Hall
20.10.2025
20:45 – 21:30h
Keynote Lecture
Chair: Stephanie Xie
What makes a stem cell a stem cell and how does it go bad during aging and leukemogenesis
John Dick
20:45h - 21:30h

Keynote Lecture
Lecture Hall
21.10.2025
17:00 – 17:45h
Keynote Lecture
Chair: Sidd Jaiswal
Stem cell Pathways Aging and Cancer Evolution
Catriona Jamieson
17:00h - 17:45h

Lectures
Lecture Hall
22.10.2025
08:30 – 10:30h
Clonal Hematopoiesis
Chair: Len Zon
Dual Stem–Myeloid Adaptations Sustain TET2 Clonal Haematopoiesis
Dominique Bonnet
08:30h - 09:00h

Lectures
Lecture Hall
22.10.2025
08:30 – 10:30h
Clonal Hematopoiesis
Chair: Len Zon
Long­term single live cell quantification: New tools for old questions
Timm Schroeder
09:00h - 09:30h

Lectures
Lecture Hall
22.10.2025
08:30 – 10:30h
Clonal Hematopoiesis
Chair: Len Zon
Identifying and quantitating selective stem cell advantage of in human clonal hematopoiesis that is associated with attenuated response to inflammation and aging
Paresh Vyas
09:30h - 10:00h

Lectures
Lecture Hall
22.10.2025
11:00 – 13:10h
Leukemia and MDS
Chair: Nina Cabezas-Wallscheid
The EMBO Keynote Lecture:LSC heterogeneity mediates response and resistance to anti-BCL2 therapy
Andreas Trumpp
11:00h - 11:40h

Lectures
Lecture Hall
22.10.2025
11:00 – 13:10h
Leukemia and MDS
Chair: Nina Cabezas-Wallscheid
Aging-driven inflametabolic changes of the niche induces drug resistance in acute myeloid leukemia
Jean Emanuel Sarry
11:40h - 12:10h

Lectures
Lecture Hall
22.10.2025
11:00 – 13:10h
Leukemia and MDS
Chair: Nina Cabezas-Wallscheid
Epigenetic Inhibitors Rewire Replication Fork Dynamics and Sensitize MLL-AML to PARP Blockade
Eric So
12:10h - 12:40h

Keynote Lecture
Lecture Hall
22.10.2025
14:30 – 15:15h
Keynote Lecture
Chair: Catriona Jamieson
The geography of acute myeloid leukemia: lessons from single cell and spatial profiling
Iannis Aifantis
14:30h - 15:15h

Lectures
Lecture Hall
23.10.2025
08:30 – 10:30h
Innovative technologies in the study of aging in hematopoiesis
Chair: Konstantinos Kokkaliaris
TET2 mutations promote clonal hematopoiesis through silencing of the E3 ubiquitin ligase TRIM4
Eirini Papapetrou
08:30h - 09:00h

Lectures
Lecture Hall
23.10.2025
08:30 – 10:30h
Innovative technologies in the study of aging in hematopoiesis
Chair: Konstantinos Kokkaliaris
Reducing nuclear stretching rejuvenates aged hematopoietic stem cells
Maria Carolina Florian
09:00h - 09:30h

Lectures
Lecture Hall
23.10.2025
08:30 – 10:30h
Innovative technologies in the study of aging in hematopoiesis
Chair: Konstantinos Kokkaliaris
Origins and Consequences of Blood Stem Cell Heterogeneity
Alejo Rodriguez-Fraticelli
09:30h - 10:00h

Keynote Lecture
Lecture Hall
23.10.2025
11:00 – 11:45h
Keynote Lecture
Chair: Claudia Waskow
Emmanuelle Passegué
Cytoprotective nucleolar stress response engagement provides resilience during hematopoietic stem cell aging
11:00h - 11:45h

Lectures
Lecture Hall
23.10.2025
11:45 – 13:15h
Therapeutics
Chair: Eric So
A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Simon Haas
11:45h - 12:15h

Lectures
Lecture Hall
23.10.2025
11:45 – 13:15h
Therapeutics
Chair: Eric So
Harnessing host immunity in the therapies of acute myeloid leukaemia
Anskar Leung
12:15h - 12:45h

Keynote Lecture
Lecture Hall
21.10.2025
11:00 – 11:45h
Company of Biologists Keynote Lecture
Chair: Eirini Trompouki
Clonal Switching Drives Adult Hematopoiesis and is Disrupted in Germline Marrow Disorders
Len Zon
11:00h - 11:45h

Lectures
Lecture Hall
21.10.2025
08:30 – 10:30h
Aging in hematopoiesis I: bone marrow niche and microenvironment
Chair: Dominique Bonnet
Short Oral Presentations: Hematopoietic stem cell aging occurs in two molecularly and functionally distinct phases
Melissa Proven
10:00h - 10:15h

Lectures
Lecture Hall
21.10.2025
08:30 – 10:30h
Aging in hematopoiesis I: bone marrow niche and microenvironment
Chair: Dominique Bonnet
Short Oral Presentations: Lack of MDA5 delays Hematopoietic stem cells aging partly by retaining proteostasis
Giang To Vu
10:15h - 10:30h

Lectures
Lecture Hall
21.10.2025
11:45 – 13:45h
Aging in hematopoiesis II: inflammation
Chair: Paresh Vyas
Short Oral Presentations: An inflammatory and quiescent HSC subset expands with age in humans
Peter van Galen
12:45h - 13:00h

Lectures
Lecture Hall
21.10.2025
11:45 – 13:45h
Aging in hematopoiesis II: inflammation
Chair: Paresh Vyas
Short Oral Presentations: Metabolic control of B cell epigenome degenerates during aging and lymphomagenesis
Beatrice Calciolari
13:00h - 13:15h

Lectures
Lecture Hall
21.10.2025
14:30 – 16:30h
Aging in hematopoiesis III: contribution to systemic aging
Chair: Andreas Trumpp
Short Oral Presentations: S1P signaling regulates diurnal CPT1a expression and calcium homeostasis in primitive hematopoietic stem cells
Priyasmita Chakrabarti
16:00h - 16:15h

Lectures
Lecture Hall
21.10.2025
14:30 – 16:30h
Aging in hematopoiesis III: contribution to systemic aging
Chair: Andreas Trumpp
Short Oral Presentations: Megakaryocytes sense infection in vivo and prime adjacent hematopoietic stem cells by localized IL-1β secretion
Yang Zhang
16:00h - 16:15h

Lectures
Lecture Hall
22.10.2025
08:30 – 10:30h
Clonal Hematopoiesis
Chair: Len Zon
Short Oral Presentations: Mapping transcriptional changes of the stromal bone marrow microenvironment in human clonal haematopoiesis
Susann Rahmig
10:00h - 10:15h

Lectures
Lecture Hall
22.10.2025
08:30 – 10:30h
Clonal Hematopoiesis
Chair: Len Zon
Short Oral Presentations: Metabolic Control of Chromatin Accessibility Reverses Age-Related Dysfunction in Human Hematopoietic Stem and Progenitor Cells
Giacomo Farina
10:00h - 10:15h

Lectures
Lecture Hall
22.10.2025
11:00 – 13:10h
Leukemia and MDS
Chair: Nina Cabezas-Wallscheid
Short Oral Presentations: Transcriptional alterations in the bone marrow cells of myelodysplastic syndrome patients with mutations in the cohesin subunit STAG2 are indicative of reduced sensitivity of hematopoietic stem cells
René Winkler
12:40h - 12:55h

Lectures
Lecture Hall
22.10.2025
11:00 – 13:10h
Leukemia and MDS
Chair: Nina Cabezas-Wallscheid
Short Oral Presentations: KDM6A restrains endoplasmic reticulum stress-dependent cell surface calreticulin and anti-tumor immunity in acute myeloid leukemia
Amitava Sengupta
12:55h - 13:10h

Lectures
Lecture Hall
23.10.2025
08:30 – 10:30h
Innovative technologies in the study of aging in hematopoiesis
Chair: Konstantinos Kokkaliaris
Short Oral Presentations: Building Human Embryo Models to Sustain and Expand Hematopoietic Stem Cells
Mo Ebrahimkhani
10:00h - 10:15h

Lectures
Lecture Hall
23.10.2025
08:30 – 10:30h
Innovative technologies in the study of aging in hematopoiesis
Chair: Konstantinos Kokkaliaris
Short Oral Presentations: Meeting the challenge of human bone marrow ageing: A standardized 3D model to decipher BMP4 signaling alterations we identified to be associated with ageing and leukemia
Lea Torcq
10:15h - 10:30h

Lectures
Lecture Hall
23.10.2025
11:45 – 13:15h
Therapeutics
Chair: Eric So
Short Oral Presenations: Targeting mitochondria mitigates chemotherapy-induced bone marrow dysfunction
Tim van Tienhoven
12:45h - 13:00h

Lectures
Lecture Hall
23.10.2025
11:45 – 13:15h
Therapeutics
Chair: Eric So
Short Oral Presenations: Targeting the EBF1-ITGB8 Axis in the Bone Marrow Niche as a Therapeutic Approach for Myelofibrosis
Marta Derecka
13:00h - 13:15h

Opening remarks
Lecture Hall
20.10.2025
20:15 – 20:45h
Opening remarks & Welcome Adresses from FEBS
Welcome Addresses from FEBS
Professor Tamas Aranyi, Member of FEBS Advanced Courses Committee
20:25h - 20:35h

Opening remarks
Lecture Hall
20.10.2025
20:15 – 20:45h
Opening remarks & Welcome Adresses from FEBS
Welcome Addresses from FEBS
Dr Julija Hmeljak, Managing Editor, FEBS Journal
20:35h - 20:45h

Lectures
Lecture Hall
23.10.2025
15:15 – 16:15h
Meet-the-editors session
Chair: John Strouboulis

Julija Hmeljak, FEBS Journal
15:15h - 15:35h

Lectures
Lecture Hall
23.10.2025
15:15 – 16:15h
Meet-the-editors session
Chair: John Strouboulis

Stylianos Lefkopoulos, Nature Cell Biology
15:35h - 15:55h

Lectures
Lecture Hall
23.10.2025
15:15 – 16:15h
Meet-the-editors session
Chair: John Strouboulis

Charlotte Mannell, Frontiers in Hematology
15:55h - 16:15h

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